A key issue in developmental biology at that time was the problem of how cells underwent differentiation, with most workers concentrating on explanations in terms of changes in enzyme and gene regulation. Paul Nurse
After an extensive interview he arranged for my weaknesses in foreign languages to be over-looked and so I started a Biology degree at Birmingham in 1967. Paul Nurse
Better understanding of the natural world not only enhances all of us as human beings, but can also be harnessed for the better good, leading to improved health and quality of life. Paul Nurse
I decided that the University of Sussex in Brighton was a good place for this work because it had a strong tradition in bacterial molecular genetics and an excellent reputation in biology. Paul Nurse
I felt strongly that since the pursuit of good science was so difficult it was essential that the problem being studied was an important one to justify the effort expanded. Paul Nurse
I had a great time investigating the pigments of different mutant fruit flies by following experimental protocols published in Scientific American, and I also remember making my own beetle collection when it was still acceptable to make such collections. Paul Nurse
I met my wife Anne who was a sociology student, and her influence together with activities associated with the student movement of the time opened up my interests amongst other things into the theatre, art, music, politics and philosophy. Paul Nurse
I was never very good at exams, having a poor memory and finding the examination process rather artificial, and there never seemed to be enough time to follow up things that really interested me. Paul Nurse
Like many students, I found the drudgery of real experiments and the slowness of progress a complete shock, and at my low points I contemplated other alternative careers including study of the philosophy or sociology of science. Paul Nurse
My main efforts focussed on trying to identify the rate controlling steps during the cell cycle. Crucial for this analysis were wee mutants that were advanced prematurely through the cell cycle and so divided at a reduced cell size. Paul Nurse
My parents were born in Norfolk and spent their early years working in the big houses of that rural English county, my mother as a cook and my father as a handyman and chauffeur. Paul Nurse
